Synthesis and evaluation of cerebroprotective activity of novel 6,7-dimethoxyquinazolin-4(3<i>H</i>)-one derivatives containing residues of amino acids and dipeptides

Neurodegenerative processes of the central nervous system are an important socially significant problem modern society. They cause many diseases, such as Alzheimer's disease and cerebral ischemia, which significantly reduce quality human life can lead to disability or death. The aim this study was synthesize novel 6,7-dimethoxyquinazolin-4(3H)-one derivatives with remains neuroactive amino acids dipeptides in order investigate their cerebroprotective properties. As a result study, 13 6,7-dimetho-xyquinazolin-4(3H)-one were synthesized. Cerebral ischemia rats reproduced by irreversible right-sided occlusion middle artery using Tamura method, area brain necrosis evaluated. Cognitive functions evaluated Y-maze test. Among studied quinazolinone derivatives, compounds 3i, 3j 3k have most pronounced cerebrotropic activity, is not inferior ethylmethylhydroxypyridine succinate terms pharmacological making them promising objects for further research.